Song Zhang, PhD 
Professor
Department of Biochemistry and Molecular Biology
College of Life Sciences
Deputy Director, Institute for Immunology
Nankai University
Research Field: Immunology
Expertise: T cell; TGF-beta; Th17; Autoimmune disease
Academic Roles
Deputy Director of Institute for Immunology, Nankai University (2021-present)
Committee member of Society for Leukocyte Biology Professional Development (2017-2019)
Cellular Immunology committee member of Chinese Society for Cell Biology (2019-present)
Basic Immunology executive committee member of Chinese Society for Immunology (2023-present)
Ambassador of Society for Leukocyte Biology (SLB) (2017-present)
Consultant of Beijing Laboratory Animal Research Center (2020-present)
Grant reviewer for Czech Science Foundation (2018-present)
External reviewer for Research Grants Council (RGC) of Hong Kong (2022-present)
Fellowship reviewer for Hong Kong Jockey Club Charities Trust (2024-present)
Guest Editor for Molecular Immunology (2017-2019)
Topic Editor for Frontiers in Immunology (2021-present)
Youth Editor for Innovation (2021-present)
Chief Editor for Virus & Immunity (2022-present)
Selected publications:
First-authored or corresponding-authored research articles: Nature Nanotechnol.2024, PNAS 2022, Nature 2017, Immunity 2015, Hepatology 2013
Wei T, Pan T, Peng X, Zhang M, Guo R, Guo Y, Mei X, Zhang Y, Qi J, Dong F, Han M, Kong F, Zou L, Li D, Zhi D, Wu W, Kong D, , Zhang S*, Zhang C*. Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds. Nat. Nanotechnol. 2024. doi: 10.1038/s41565-024-01660-y. (*Co-corresponding)
Zhang R, Yang Y, Dong W, Lin M, He J, Zhang X, Tian T, Yang Y, Chen K, Lei QY, Zhang S*, Xu Y*, Lv L*. D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1. Proc. Natl. Acad. Sci. USA. 2022;119(8). Epub 2022/02/20. doi: 10.1073/pnas.2114851119. PubMed PMID: 35181605. (*Co-corresponding)
Zhang S, Takaku M, Zou L, Gu AD, Chou WC, Zhang G, Wu B, Kong Q, Thomas SY, Serody JS, Chen X, Xu X, Wade PA, Cook DN, Ting JPY, Wan YY. Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature. 2017;551(7678):105-9. doi: 10.1038/nature24283. PubMed PMID: 29072299 (First-author)
Gu AD#, Zhang S#, Wang Y, Xiong H, Curtis TA, Wan YY. A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor beta receptor signaling. Immunity. 2015;42(1):68-79. doi: 10.1016/j.immuni.2014.12.019. PubMed PMID: 25577439 (#Co-first author)
Zhang S, Liang R, Luo W, Liu C, Wu X, Gao Y, Hao J, Cao G, Chen X, Wei J, Xia S, Li Z, Wen T, Wu Y, Zhou X, Wang P, Zhao L, Wu Z, Xiong S, Gao X, Gao X, Chen Y, Ge Q, Tian Z, Yin Z. High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-gamma dysregulation of CD4+ T cells. Hepatology. 2013;57(4):1620-31. doi: 10.1002/hep.26166. PubMed PMID: 23175475 (First-author)
Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. AIM2 in regulatory T cells restrains autoimmune diseases. Nature. 2021;591(7849):300-5. Epub 2021/01/29. doi: 10.1038/s41586-021-03231-w. PubMed PMID: 33505023
Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, Seyedsadr M, Xu X, Li JL, Markovic-Plese S, Wan YY. The TGF-beta superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Immunity. 2021;54(2):308-23 e6. Epub 2021/01/10. doi: 10.1016/j.immuni.2020.12.010. PubMed PMID: 33421362
Zhang S*. The role of transforming growth factor beta in T helper 17 differentiation. Immunology. 2018;155(1):24-35. doi: 10.1111/imm.12938. PubMed PMID: 29682722 (Commissioned review article.)
Wu B, Zhang S, Guo Z, Wang G, Zhang G, Xie L, Lou J, Chen X, Wu D, Bergmeier W, Zheng J, Wan YY. RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs. Immunity. 2018;49(5):886-98 e5. Epub 2018/11/18. doi:10.1016/j.immuni.2018.09.004. PubMed PMID: 30446383
Li X, Deng M, Petrucelli AS, Zhu C, Mo J, Zhang L, Tam JW, Ariel P, Zhao B, Zhang S, Ke H, Li P, Dokholyan NV, Duncan JA, Ting JP. Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon. Immunity. 2019;50(3):591-9 e6. Epub 2019/03/21. doi: 10.1016/j.immuni.2019.02.009. PubMed PMID: 30893587